Detalhe da pesquisa
1.
Improving In Vitro-In Vivo Extrapolation of Clearance Using Rat Liver Microsomes for Highly Plasma Protein-Bound Molecules.
Drug Metab Dispos
; 52(5): 345-354, 2024 Apr 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-38360916
2.
Absorption, Distribution, Metabolism, and Excretion of [14C]iptacopan in Healthy Male Volunteers and in In Vivo and In Vitro Studies.
Drug Metab Dispos
; 51(7): 873-883, 2023 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-37308298
3.
The application of organ-on-chip models for the prediction of human pharmacokinetic profiles during drug development.
Pharmacol Res
; 195: 106853, 2023 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-37473876
4.
Simplifying the Extended Clearance Concept Classification System (EC3S) to Guide Clearance Prediction in Drug Discovery.
Pharm Res
; 40(4): 937-949, 2023 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-36859748
5.
Human Pharmacokinetics of LYS006, an Oral Leukotriene A4 Hydrolase Inhibitor Displaying Target-Mediated Drug Disposition.
Drug Metab Dispos
; 50(12): 1472-1482, 2022 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-36195338
6.
Time matters - in vitro cellular disposition kinetics help rationalizing cellular potency disconnects.
Xenobiotica
; 52(8): 878-889, 2022 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-36189672
7.
Clinical Investigation of Metabolic and Renal Clearance Pathways Contributing to the Elimination of Fevipiprant Using Probenecid as Perpetrator.
Drug Metab Dispos
; 49(5): 389-394, 2021 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-33632715
8.
A Systematic In Vitro Investigation of the Inhibitor Preincubation Effect on Multiple Classes of Clinically Relevant Transporters.
Drug Metab Dispos
; 47(7): 768-778, 2019 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-31068368
9.
Fevipiprant has a low risk of influencing co-medication pharmacokinetics: Impact on simvastatin and rosuvastatin in different SLCO1B1 genotypes.
Pulm Pharmacol Ther
; 57: 101809, 2019 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-31195091
10.
Assessing the Risk of Drug-Induced Cholestasis Using Unbound Intrahepatic Concentrations.
Drug Metab Dispos
; 45(5): 523-531, 2017 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-28254950
11.
Fevipiprant (QAW039) does not affect the pharmacokinetics of zidovudine, its glucuronide, and penicillin G via inhibition of UGT2B7 and/or OAT3.
Pulm Pharmacol Ther
; 72: 102097, 2022 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-34800680
12.
Prediction of organic anion-transporting polypeptide 1B1- and 1B3-mediated hepatic uptake of statins based on transporter protein expression and activity data.
Drug Metab Dispos
; 42(9): 1514-21, 2014 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-24989890
13.
LTA4H inhibitor LYS006: Clinical PK/PD and safety in a randomized phase I clinical trial.
Clin Transl Sci
; 17(2): e13724, 2024 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-38407540
14.
Novel insights into bile acid detoxification via CYP, UGT and SULT enzymes.
Toxicol In Vitro
; 87: 105533, 2023 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-36473578
15.
Brain accumulation of sunitinib is restricted by P-glycoprotein (ABCB1) and breast cancer resistance protein (ABCG2) and can be enhanced by oral elacridar and sunitinib coadministration.
Int J Cancer
; 130(1): 223-33, 2012 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-21351087
16.
P-glycoprotein (ABCB1) and breast cancer resistance protein (ABCG2) restrict brain accumulation of the active sunitinib metabolite N-desethyl sunitinib.
J Pharmacol Exp Ther
; 341(1): 164-73, 2012 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-22238213
17.
Novel Bruton's Tyrosine Kinase inhibitor remibrutinib: Drug-drug interaction potential as a victim of CYP3A4 inhibitors based on clinical data and PBPK modeling.
Clin Transl Sci
; 15(1): 118-129, 2022 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-34432364
18.
Differential impact of P-glycoprotein (ABCB1) and breast cancer resistance protein (ABCG2) on axitinib brain accumulation and oral plasma pharmacokinetics.
Drug Metab Dispos
; 39(5): 729-35, 2011 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-21282407
19.
Double-transduced MDCKII cells to study human P-glycoprotein (ABCB1) and breast cancer resistance protein (ABCG2) interplay in drug transport across the blood-brain barrier.
Mol Pharm
; 8(2): 571-82, 2011 Apr 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-21309545
20.
Predicting Oral Absorption for Compounds Outside the Rule of Five Property Space.
J Pharm Sci
; 110(6): 2562-2569, 2021 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-33539870